Dendritic cell control of tolerogenic responses
نویسندگان
چکیده
منابع مشابه
Tolerogenic dendritic cell-based immunotherapy
Dendritic cells (DC) are established T-cell immunity inducers [1], and are also being viewed increasingly as T-cell tolerance mediators [2, 3]. Normally, DCs regulate immune homeostasis by maintaining the balance between T cell immunity and tolerance. Thus far, DC-based immunotherapy has been primarily a consideration in the field of cancer therapy (for the treatment of cancers using fully matu...
متن کاملDendritic Cell Control of Immune Responses
Dendritic cells (DC) play a critical role in the initiation of the immune response, acting as sentinels in the tissues, reacting to invading pathogens and then inducing the activation and differentiation of naïve T cells. Since their discovery by Ralph Steinman in the 1970s, we have learned a great deal about DC biology and function. Distinct DC subsets exist in specific tissue niches and withi...
متن کاملTolerogenic dendritic cells.
Dendritic cells (DCs) have several functions in innate and adaptive immunity. In addition, there is increasing evidence that DCs in situ induce antigen-specific unresponsiveness or tolerance in central lymphoid organs and in the periphery. In the thymus DCs generate tolerance by deleting self-reactive T cells. In peripheral lymphoid organs DCs also induce tolerance to antigens captured by recep...
متن کاملCD40 Knocked Down Tolerogenic Dendritic Cells Decrease Diabetic Injury
Background: Type-1 diabetes (T1D) is an autoimmune disease in which T lymphocytes destroy insulin-producing β-cells. Control of self-reactive T lymphocytes and recovery of diabetic injury is the end point of T1D. Objective: To investigate generation of tolerogenic dendritic cells (tolDCs) as an innovative method of diabetes therapy. Methods: Lentivirus vector production was achieved by GIPZ mou...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Immunological Reviews
سال: 2011
ISSN: 0105-2896
DOI: 10.1111/j.1600-065x.2011.01015.x